Annual report pursuant to Section 13 and 15(d)

Stockholders' Equity (Deficit) (Details Textual)

v3.3.1.900
Stockholders' Equity (Deficit) (Details Textual) - USD ($)
 1 Months Ended 2 Months Ended 3 Months Ended 12 Months Ended
Oct. 31, 2014
Nov. 30, 2013
Apr. 30, 2013
Mar. 31, 2013
Mar. 31, 2013
Dec. 31, 2015
Dec. 31, 2014
Dec. 31, 2013
Apr. 30, 2012
Mar. 15, 2011
Class of Warrant or Right [Line Items]                    
Proceeds from Warrant Exercises           $ 0 $ 0 $ 1,275,000    
Underwritten Public Offering, Proceeds from Units Issued $ 9,600,000                  
Stockholders' Equity, Reverse Stock Split           1 for 5.5 reverse stock split effected in September 2015        
Common Stock, Par or Stated Value Per Share           $ 0.001 $ 0.001      
Series A Warrants [Member]                    
Class of Warrant or Right [Line Items]                    
Class of Warrant or Right Exercised During Period               201,639    
Proceeds from Warrant Exercises               $ 1,275,000    
Class of Warrant or Right, Exercise Price of Warrants or Rights $ 4.89                  
Deerfield Warrant [Member]                    
Class of Warrant or Right [Line Items]                    
Class of Warrant or Right Exercised During Period       1,090,910            
Debt Instrument, Increase (Decrease), Net, Total       $ 7,500,000            
Class of Warrant or Right, Exercise Price of Warrants or Rights                 $ 6.88 $ 8.64
Class A Warrant [Member]                    
Class of Warrant or Right [Line Items]                    
Class of Warrant or Right Exercised During Period         201,639          
Proceeds from Warrant Exercises         $ 1,275,000          
Class of Warrant or Right, Exercise Price of Warrants or Rights $ 3.30                  
Former Lender [Member]                    
Class of Warrant or Right [Line Items]                    
Conversion of Stock, Shares Issued     26,273              
Class of Warrant or Right Exercised During Period     52,247              
Stock Purchase And Option Agreement With Affiliate [Member]                    
Class of Warrant or Right [Line Items]                    
Stock Issued During Period, Shares, New Issues   1,136,000                
Proceeds from Issuance of Common Stock   $ 5,000,000                
Sale of Stock, Price Per Share   $ 4.40