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Commitments and Contingencies (Details Textual) (USD $)
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1 Months Ended | 12 Months Ended | 1 Months Ended | 12 Months Ended | 1 Months Ended | 0 Months Ended | 1 Months Ended | ||||||
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Mar. 15, 2011
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Dec. 31, 2013
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Dec. 31, 2012
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Dec. 31, 2011
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Dec. 31, 2010
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Sep. 30, 2012
Oxford Capital Financing [Member]
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Sep. 30, 2010
Oxford Capital Financing [Member]
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Dec. 31, 2009
Oxford Capital Financing [Member]
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Nov. 14, 2011
Deerfield Promissory Notes [Member]
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Mar. 15, 2011
Deerfield Promissory Notes [Member]
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Apr. 05, 2011
Deerfield Promissory Notes [Member]
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Mar. 15, 2011
Deerfield Promissory Notes [Member]
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Apr. 30, 2012
Deerfield Promissory Notes [Member]
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| Commitments and Contingencies | |||||||||||||
| Debt Instrument, Face Amount | $ 20,000,000 | $ 20,000,000 | |||||||||||
| Debt Instrument, Periodic Payment Terms, Balloon Payment to be Paid | 480,000 | 480,000 | |||||||||||
| Warrants, Term | 5 years | 5 years | 6 years | ||||||||||
| Repayments of Long-term Debt, Total | 2,500,000 | 393,000 | 7,564,000 | 7,600,000 | |||||||||
| Debt Instrument, Interest Rate, Stated Percentage | 8.50% | 8.50% | |||||||||||
| Debt instrument periodic payment | annual | ||||||||||||
| Percentage of principle amount due in year one | 10.00% | ||||||||||||
| Percentage of principle amount due in year two | 15.00% | ||||||||||||
| Percentage of principle amount due on each of the next three anniversaries | 25.00% | ||||||||||||
| Principle amount repayment percentage | 110.00% | ||||||||||||
| Debt Instrument, Cash Discount | 3,000,000 | 3,000,000 | |||||||||||
| Accrued Royalties | 5,000,000 | 3,000,000 | 3,000,000 | ||||||||||
| Long-term Debt, Gross | 10,000,000 | ||||||||||||
| Rent expense under operating leases | 210,000 | 214,000 | 257,000 | ||||||||||
| Repayments of Debt | 2,500,000 | ||||||||||||
| Gains (Losses) on Extinguishment of Debt, Total | 1,860,000 | 0 | 0 | ||||||||||
| Debt Instrument, Term | 39 months | 3 years | |||||||||||
| Debt Instrument, Fee Amount | 500,000 | 500,000 | |||||||||||
| Warrants To Purchase Common Stock | 6,000,000 | ||||||||||||
| Warrants, Exercise Price | $ 1.57 | $ 1.57 | |||||||||||
| Adjustments to Additional Paid in Capital, Warrant Issued | 5,500,000 | 255,000 | 89,000 | ||||||||||
| Debt Instrument, Unamortized Discount | 9,000,000 | 9,000,000 | |||||||||||
| Extinguishment of Debt, Amount | 7,500,000 | 10,000,000 | |||||||||||
| Debt Instrument, Periodic Payment, Principal | 2,500,000 | ||||||||||||
| Debt Instrument Periodic Payment Number of Years | 4 years | ||||||||||||
| Warrants, Adjusted Exercise Price | $ 1.25 | ||||||||||||
| Operating Leases, Rent Expense | $ 210,000 | $ 203,000 | $ 214,000 | ||||||||||