Annual report pursuant to Section 13 and 15(d)

Organization and Summary of Significant Accounting Policies (Details Textual)

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Organization and Summary of Significant Accounting Policies (Details Textual) (USD $)
 12 Months Ended 1 Months Ended 12 Months Ended
Dec. 31, 2013
Dec. 31, 2012
Dec. 31, 2011
Dec. 31, 2010
Nov. 12, 2013
Collaborative Arrangement Co-promotion [Member]
Dec. 31, 2012
Collaborative Arrangement Co-promotion [Member]
Schedule of Organization and Summary of Significant Accounting Policies [Line Items]            
Non-refundable up-front payment           $ 15,750,000
License and services revenue           15,000,000
Milestone payment           15,000,000
Additional amount received upon achievement of sales milestones         165,000,000 165,000,000
Additional amount in regulatory milestones         35,000,000 35,000,000
Cash 11,798,000 18,102,000 5,406,000 3,180,000    
Non-cash stock-based compensation expense 678,000 2,581,000 1,177,000      
Comprehensive Income (Loss), Net of Tax, Attributable to Parent, Total 9,700,000 15,200,000        
Non-Cash Gain (Loss) on Changes in Fair Value of Warrants $ 1,737,000 $ (1,766,000) $ 1,862,000