Annual report pursuant to Section 13 and 15(d)

Commitments and Contingencies (Details Textual)

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Commitments and Contingencies (Details Textual) (USD $)
 1 Months Ended 12 Months Ended 12 Months Ended
Nov. 30, 2011
Apr. 05, 2011
Mar. 15, 2011
Sep. 30, 2010
Dec. 31, 2009
Dec. 31, 2012
Dec. 31, 2011
Dec. 31, 2010
Sep. 30, 2010
Dec. 31, 2009
Nov. 14, 2011
Apr. 30, 2012
Deerfield Warrant [Member]
Dec. 31, 2012
Office Equipment [Member]
Commitments and Contingencies (Additional Textual) [Abstract]                          
Operating lease expiration period           2013-06             2013-12
Commitments and Contingencies (Textual) [Abstract]                          
Loan term       P39M P3Y                
Loan principal amount     $ 20,000,000 $ 5,000,000 $ 3,000,000       $ 5,000,000 $ 3,000,000      
Bearing interest rate       13.00% 13.00%       13.00% 13.00%      
Facility fee     500,000 125,000 60,000                
Final payment of principal amount     480,000 300,000 180,000       300,000 180,000      
Monthly interest payment       54,167 32,500                
Monthly interest and principal amount installments       196,108 117,665                
Warrants periodic payments     6 years 5 years 5 years                
Purchase of common stock for warrants     6,000,000 287,356 42,254       287,356 42,254      
Issuance Costs     1.57 0.87 2.13       0.87 2.13   1.25  
Fair value of warrants     5,500,000 254,580 88,995       254,580 88,995      
Effective annual interest rate on loan 67.30%   43.10%           22.60% 21.10%      
Funding from Deerfield     20,000,000                    
Proceeds from the Deerfield funding to repay Oxford in full   7,600,000                      
Interest rate on long-term debt     8.50%                    
Debt instrument periodic payment     Payable quarterly, and was originally repayable over five years                    
Long term debt repayment period     5 years                    
Percentage of principle amount due in year one     10.00%                    
Percentage of principle amount due in year two     15.00%                    
Percentage of principle amount due on each of the next three anniversaries     25.00%                    
Principle amount repayment percentage     110.00%                    
Royalty revenue     3,000,000     4,750,000 3,585,000 2,512,000          
Debt discount     3,000,000                    
Loan fee     500,000                    
Total amortized discount     9,000,000                    
Effective annual interest rate     33.00%                    
Royalty liability     3,000,000               5,000,000    
Reduction in the principal amount owed to Deerfield                     10,000,000    
Revised principal repayment in 2013           3,049,000         2,500,000    
Revised principal repayment in 2014           2,836,000         2,500,000    
Revised principal repayment in 2015           2,624,000         2,500,000    
Revised principal repayment in 2016                     2,500,000    
Remaining long-term debt to be retired                     10,000,000    
Facility agreement amount 20,000,000                        
Percentage of aggregate royalties on net sales     2.50%                    
Royalty rights     40,000,000                    
Rent expense under operating leases           $ 203,000 $ 214,000 $ 257,000