Annual report pursuant to Section 13 and 15(d)

Property and Equipment (Details)

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Property and Equipment (Details) - USD ($)
$ in Thousands
Dec. 31, 2017
Dec. 31, 2016
Property, Plant and Equipment [Line Items]    
Property, Plant and Equipment, Gross $ 4,654 $ 4,479
Less accumulated depreciation and amortization (4,059) (3,642)
Property and equipment, net 595 837
Furniture and office equipment [Member]    
Property, Plant and Equipment [Line Items]    
Property, Plant and Equipment, Gross 388 388
Leasehold improvements [Member]    
Property, Plant and Equipment [Line Items]    
Property, Plant and Equipment, Gross 408 408
Laboratory equipment [Member]    
Property, Plant and Equipment [Line Items]    
Property, Plant and Equipment, Gross 2,690 2,548
Computer equipment [Member]    
Property, Plant and Equipment [Line Items]    
Property, Plant and Equipment, Gross $ 1,168 $ 1,135