Quarterly report pursuant to Section 13 or 15(d)

Commitments and Contingencies (Details Textual)

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Commitments and Contingencies (Details Textual) (USD $)
1 Months Ended 3 Months Ended 12 Months Ended 3 Months Ended 1 Months Ended
Mar. 15, 2011
Mar. 31, 2014
Mar. 31, 2013
Dec. 31, 2013
Mar. 31, 2014
Sanofi-Aventis SA [Member]
Mar. 31, 2013
Sanofi-Aventis SA [Member]
Dec. 31, 2013
Sanofi-Aventis SA [Member]
Nov. 14, 2011
Deerfield Promissory Notes [Member]
Mar. 15, 2011
Deerfield Promissory Notes [Member]
Apr. 30, 2012
Deerfield Promissory Notes [Member]
Commitments and Contingencies                    
Debt Instrument, Face Amount                 $ 20,000,000  
Debt Instrument, Interest Rate, Stated Percentage                 8.50%  
Debt instrument periodic payment               annual    
Percentage of principle amount due in year one                 10.00%  
Percentage of principle amount due in year two                 15.00%  
Percentage of principle amount due on each of the next three anniversaries                 25.00%  
Debt Instrument, Cash Discount                 3,000,000  
Accrued Royalties               5,000,000 3,000,000  
Long-term Debt, Gross               10,000,000    
Repayments of Debt       2,500,000            
Gains (Losses) on Extinguishment of Debt, Total   0 1,860,000              
Debt Instrument, Fee Amount                 500,000  
Warrants To Purchase Common Stock                 6,000,000  
Warrants, Exercise Price                 $ 1.57  
Adjustments to Additional Paid in Capital, Warrant Issued 5,500,000                  
Debt Instrument, Unamortized Discount                 9,000,000  
Extinguishment of Debt, Amount       7,500,000       10,000,000    
Debt Instrument, Periodic Payment, Principal               2,500,000    
Debt Instrument Periodic Payment Number of Years               4 years    
Warrants, Adjusted Exercise Price                   $ 1.25
Royalty Revenue   0 1,424,000   17,300,000 17,800,000        
Accrued Royalties, Current         $ 2,600,000   $ 3,100,000